Due to the resumption of European Cup football, a number of the high-profile teams will be afforded a rest on Saturday.
However, the likes of Manchester City and Manchester United will still be involved with the former welcoming Nottingham Forrest whilst the Reds travel to Turfmore to face Burnley.
Luton will aim for their first win of the season when they host Wolves as Crystal Palace are at home to Crystal Palace.
Find below the BestBet’s predictions of this weekend’s games:
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Crystal Palace
Manchester United
Fulham FC
Manchester City
AFC Bournemouth
Brentford FC
Everton FC
Sheffield United
Newcastle United
Brighton & Hove Albion
Tottenham
Burnley FC
West Ham United
Luton Town
Wolverhampton Wanderers
Nottingham Forest
Chelsea FC
Arsenal FC
Aston Villa
Liverpool FC
